Endocrine Abstracts

Central pontine myelinolysis (CPM) is a neurological disorder typically caused by rapid correction of severe chronic hyponatremia. Conditions causing a hyperosmolar state can also cause CPM, but it is rarely seen in diabetes. We report the case of a 33-year-old woman with personal history of Type 1 Diabetes since she was 9 years old with very poor metabolic control (A1hbC 15%) and microvascular complications, who attended the emergency department due to left hemicranial headac...

Introduction: Thyroid nodule is a frequent condition, being diagnosed in up to 70% of subjects who had undergone thyroid ultrasound. Around 90-95% of them became being benign and, if the do not cause compressive symptoms or esthetical problems, they do not need specific therapy, only clinical follow up. Traditionally, thyroidectomy has been the main therapeutic option in these cases. Radiofrequency and ethanol ablations are recently introduced non-invasive therapies that permi...

Pituitary adenomas (PAs) account for 15-20% of intracranial tumors. PA with a cystic component are characterized in the MRI by a sellar, symmetrical, round or ovoid mass that enhances on T1- or T2-weighted images but does not concentrate gadolinium. We present the case of a 48-year-old man who in a headache study by Neurology requested a CT scan showing a cystic pituitary macroadenoma of 1.25cm confirmed by pituitary MRI. In the initial analysis, the pituitary function was pre...

Introduction: Pituitary adenomas are considered to be benign tumors that are diagnosed by its sympthoms (secondary to compression or hormonal secretion) or incidentally in an imaging technique performed because of another reason. ‘Silent’ somatotrophinomas are very rare. This type of adenoma is typically large and despite it presents with mild or no acromegalic features it usually develops hormone secretion.A case report: A 29-year-old spanish ...

Introduction: Patients with large non-functioning pituitary macroadenomas often have symptoms due to varying degree of hypopituitarism and/or mass effect on visual structures, while presentation with hydrocephalus is extremely uncommon.Case report: We describe an 82-year-old man who was referred to the Neurology department of our hospital because of rapidly progressive memory loss. The patient was in good health until ten weeks earlier, when he insidious...

Introduction: Postprandial hypoglucaemia with hyperinsulinism after laparoscopic gastric bypass is an uncommon complication with an estimated prevalence of 0.2%. Its treatment includes acarbose, diazoxide, somatostatin and GLP-1 analogues or calcium channel blockers in case a strict diet does not work.Case report: A 42-year-old woman with history of gastric bypass in 2005 due to severe obesity (preoperative weight 150 kg) attended our clinic 3 years afte...

Objective: To describe the clinical characteristics and post-surgical outcome of our primary hyperparathyroidism case series.Methods: A retrospective cohort study of primary hyperparathyroidism patients who underwent surgery in the last 10 years in our centre. The medical records were reviewed to extract data. A statistical descriptive analysis was performed using mean and S.D. for continuous variables and percentages for qualitative varia...

Background: Women with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances, in particular from pre-diabetes and diabetes. Conflicting results currently exists on the relationship between vitamin D and glucose metabolism. Hence, the aim of our study was to investigate the association of 25-hydroxyvitamin D (25(OH)D) levels and glucose tolerance in PCOS women.Methods: Cross-sectional study including 23 PCOS patients (mean age 27 ...

Introduction: In most patients with familial history of pheochromocytoma/paraganglioma, leads in the majorty of cases to a postive genetic testing for mutations, and what’s more in those patients with no familial antecedents, about 10–25% carry a mutation in one related gene. In these cases other aspects like, bilaterality, multiplicity or location must be taken into account.Objective: The objective of the study was to discuss the importance of...

Introduction: Prolactinomas are the most common tumors among functional pituitary adenomas and they constitute 40% of all pituitary tumors. Dopamine agonists (DA) are considered the primary treatment of prolactinoma. DA can lead to complete remission (including eradicacion of the tumor), allowing discotinuation of treatment. So far, there aren’t clinical criteria with sufficient predictive value for long-term remission.Objective: To assess the effec...